Topologically Associating Domains: An invariant framework or a dynamic scaffold?
نویسندگان
چکیده
منابع مشابه
Topologically Associating Domains: An invariant framework
Metazoan genomes are organized into regions of topologically associating domains (TADs). TADs are demarcated by border elements, which are enriched for active genes and high occupancy architectural protein binding sites. We recently demonstrated that 3D chromatin architecture is dynamic in response to heat shock, a physiological stress that downregulates transcription and causes a global redist...
متن کاملEntropy gives rise to topologically associating domains
We investigate chromosome organization within the nucleus using polymer models whose formulation is closely guided by experiments in live yeast cells. We employ bead-spring chromosome models together with loop formation within the chains and the presence of nuclear bodies to quantify the extent to which these mechanisms shape the topological landscape in the interphase nucleus. By investigating...
متن کاملRapidly evolving in humans topologically associating domains
Rapidly evolving in humans topologically associating domains Gennadi V. Glinsky 2 1 Institute of Engineering in Medicine University of California, San Diego 9500 Gilman Dr. MC 0435 La Jolla, CA 92093-0435, USA Correspondence: [email protected] Web: http://iem.ucsd.edu/people/profiles/guennadi-v-glinskii.html The Stanford University School of Medicine, Medical School Lab Surge Bldg., Room P214,...
متن کاملStructural Fluctuations of the Chromatin Fiber within Topologically Associating Domains.
Experiments based on chromosome conformation capture have shown that mammalian genomes are partitioned into topologically associating domains (TADs), within which the chromatin fiber preferentially interacts. TADs may provide three-dimensional scaffolds allowing genes to contact their appropriate distal regulatory DNA sequences (e.g., enhancers) and thus to be properly regulated. Understanding ...
متن کاملMrTADFinder: A network modularity based approach to identify topologically associating domains in multiple resolutions
Genome-wide proximity ligation based assays such as Hi-C have revealed that eukaryotic genomes are organized into structural units called topologically associating domains (TADs). From a visual examination of the chromosomal contact map, however, it is clear that the organization of the domains is not simple or obvious. Instead, TADs exhibit various length scales and, in many cases, a nested ar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleus
سال: 2015
ISSN: 1949-1034,1949-1042
DOI: 10.1080/19491034.2015.1096467